Lazio aim to end their Chievo curse, but must reshuffle the midfield without Hernanes and Lucas Biglia.
The Flying Donkeys have lost only once at the Stadio Olimpico, back in 2003, and won here last season.
It kicks off at 14.00 UK time (13.00 GMT), click here for a match preview.
Vladimir Petkovic noted this week there was a lack of enthusiasm around his side and protests are planned by the ultras before the game.
Hernanes is suspended following his red card against Juventus, while Stefano Mauri is still banned awaiting an appeal in the betting scandal.
Biglia picked up a muscular problem on international duty and misses out along with Stefan Radu, so Cristian Ledesma has to take the midfield keys.
Ederson moves up to support Miroslav Klose in attack with Antonio Candreva redirected to the right flank.
Chievo are without Dario Dainelli, but Cyril Thereau aims to celebrate his contract extension by partnering Alberto Paloschi.
Lazio: Marchetti; Konko, Biava, Cana, Cavanda; Candreva, Onazi, Ledesma, Lulic; Ederson; Klose
Lazio bench: Berisha, Strakosha, Dias, Ciani, Novaretti, Gonzalez, Crecco, Floccari, Keita, Tounkara
Chievo: Puggioni; Sardo, Papp, Cesar, Dramé; Sestu, Radovanovic, L Rigoni, Hetemaj; Thereau, Paloschi
Chievo bench: Silvestri, Squizzi, Frey, Claiton, Parnic, Lazarevic, Bentivoglio, Improta, Estigarribia, Acosty, Pellissier, Ardemagni
See the latest Serie A predictions and betting tips with Eurotips.co.uk