There are three games today, while Sunday brings top clashes Roma-Lazio, Juventus with giant-killers Verona and Milan-Napoli.
The action begins today with two kick-offs at 17.00 UK time (16.00 GMT), as Sampdoria try to get over their Derby humiliation against Cagliari and Chievo test Udinese’s mettle.
This evening Genoa are still riding the wave of enthusiasm when they host impressive new boys Livorno.
Sunday opens with the lunchtime match between Serie A first timers Sassuolo and high-flying Inter, as Ezequiel Schelotto faces his parent club.
Games don’t get much bigger than the Sunday afternoon Derby della Capitale, as Roma and Lazio go head-to-head in perhaps the world’s most bitterly contested local clash.
Juventus take on Luca Toni’s Verona, Catania and Parma try to end their crises while Fiorentina visit Bergamo.
On Sunday evening there’s the Scudetto showdown at San Siro, as the wildly inconsistent Milan try to end Rafa Benitez’s 100 per cent record on the Napoli bench.
See the latest Serie A predictions and betting tips with Eurotips.co.uk