It’s an action-packed day with Inter visiting Sassuolo, then the Derby della Capitale and tonight a Milan-Napoli showdown.
Click here for previews of every single Serie A Week 4 match, plus reports on Saturday’s Chievo-Udinese, Cagliari-Sampdoria and Genoa-Livorno.
It all begins at the Mapei Stadium at 11.30am UK time (10.30 GMT) when Inter face bottom of the table Sassuolo with Ezequiel Schelotto out to prove a point.
This afternoon Juventus host giant-killers Verona, Fiorentina are tested in Bergamo, Catania and Parma try to end their crises.
All eyes will be on the Stadio Olimpico for the Rome Derby, as Roma try to keep their 100 per cent record and take revenge on Lazio.
Tonight Napoli also want to hold on to their perfect record, but to do so must earn their first Serie A win away to Milan since 1986.
See the latest Serie A predictions and betting tips with Eurotips.co.uk