It’s a Scudetto showdown at San Siro, as Mario Balotelli’s Milan take on the Napoli of Gonzalo Higuain.
It all kicks off at 19.45 UK time (18.45 GMT), click here for a match preview.
Something has to give, as Napoli’s 100 per cent record will be ended unless they can earn their first victory here since 1986.
The Rossoneri’s injury crisis continues with Kaka, Stephan El Shaarawy, Riccardo Montolivo, Giampaolo Pazzini, Mattia De Sciglio, Matias Silvestre and Daniele Bonera sidelined.
Ignazio Abate, M’Baye Niang and Andrea Poli return to give Max Allegri a few more options, but Valter Birsa is again supporting Balotelli and Alessandro Matri.
Napoli are fresh from three consecutive Serie A victories and Wednesday’s 2-1 Champions League win over Borussia Dortmund.
Lorenzo Insigne again starts with Jose Maria Callejon, Marek Hamsik and hitman ‘Pipita’ Higuain. Giandomenico Mesto steps in at right-back for Cristian Maggio.
Milan: Abbiati; Abate, Zapata, Mexes, Emanuelson; Poli, De Jong, Muntari; Birsa, Matri, Balotelli
Napoli: Reina; Mesto, Albiol, Britos, Zuniga; Dzemaili, Behrami; Insigne, Hamsik, Callejon; Higuain
See the latest Serie A predictions and betting tips with Eurotips.co.uk