The two dark horses for the Scudetto go head-to-head tonight, as Inter aim to end Roma’s 100 per cent record.
It kicks off at the Stadio Giuseppe Meazza, commonly known as San Siro, at 19.45 UK time (18.45 GMT). Click here for a match preview.
Roma have a perfect record of six consecutive victories, in which they conceded only one goal and scored 17.
Douglas Maicon is injured against his former club, joining Michael Bradley and Mattia Destro on the treatment table.
Adem Ljajic is only fit for the bench, so Gervinho starts with Francesco Totti and Alessandro Florenzi.
Daniele De Rossi, Miralem Pjanic and Kevin Strootman provide support from midfield, while Vasilis Torosidis steps in for Maicon at right-back.
Inter are also unbeaten this season and sit in fourth place after four wins and two draws, the latest being a 1-1 with Cagliari.
Walter Mazzarri is forced to reshuffle as injuries hit two of the most impressive players so far this season: Hugo Campagnaro and Jonathan.
With Cristian Chivu and Javier Zanetti also sidelined, ex-Napoli defender Rolando and Alvaro Pereira step in for the absentees.
Ricky Alvarez and Rodrigo Palacio form the exciting all-Argentine front pair, supported by Saphir Taider, Esteban Cambiasso and Fredy Guarin.
The Giallorossi have an excellent recent record at San Siro, unbeaten in their last four visits and winning two on the bounce between Serie A and Coppa Italia.
Inter: Handanovic; Rolando, Ranocchia, Juan Jesus; Nagatomo, Guarin, Cambiasso, Taider, Pereira; Alvarez, Palacio
Inter bench: Castellazzi, Carrizo, Andreolli, Samuel, Wallace, Kuzmanovic, Mudingayi, Kovacic, Belfodil, Icardi, Milito
Roma: De Sanctis; Torosidis, Benatia, Castan, Balzaretti; Pjanic, De Rossi, Strootman; Florenzi, Totti, Gervinho
Roma bench: Skorupski, Lobont, Burdisso, Romagnoli, Jedvaj, Dodò, Marquinho, Taddei, Ricci, Caprari, Ljajic, Borriello
See the latest Serie A predictions and betting tips with Eurotips.co.uk