Napoli-Torino is the intriguing early kick-off, then Juventus host Gian Piero Gasperini’s Genoa, Milan visit Parma and leaders Roma face Udinese.
Click here for all the individual match previews from Serie A Week 9, plus reports of Sampdoria-Atalanta and Inter-Verona.
It begins at 11.30am GMT at the Stadio San Paolo, as Napoli aim to get back on track against a Torino side that held Inter 3-3 last week.
This afternoon there are several difficult tests for the big teams, as leaders Roma go to the Stadio Friuli without Francesco Totti and Gervinho. Can they maintain their 100 per cent record and end Udinese’s 22-match unbeaten home run?
Juventus take on Gian Piero Gasperini’s revived Genoa, while Milan face their past at Parma in the form of Roberto Donadoni and Antonio Cassano.
Fiorentina aim to keep their remarkable form going at Chievo, while Catania Coach Rolando Maran makes his debut against Sassuolo.
This evening Lazio take on Cagliari as the pressure grows on Vladimir Petkovic.
See the latest Serie A predictions and betting tips with Eurotips.co.uk