Eugenio Corini returns for the Verona Derby, Napoli host Antonio Cassano’s Parma and Milan are under pressure against Genoa.
Serie A returns after the break for international duty, click here for match previews of every Week 13 fixture.
It kicks off at 17.00 GMT with the Derby di Verona, as high-flying Hellas try to push rivals Chievo even lower on new Coach Corini’s debut.
There are two evening games, as Napoli-Parma has Gonzalo Higuain against Cassano, while Max Allegri continues to gamble with his job in Milan-Genoa.
The action continues on Sunday with Livorno-Juventus, Sinisa Mihajlovic making his Sampdoria debut against another of his old clubs Lazio, Udinese-Fiorentina and in the evening Bologna-Inter.
Serie A leaders Roma try to get back to winning ways against Daniele Conti’s Cagliari on Monday night.
See the latest Serie A predictions and betting tips with Eurotips.co.uk