Sinisa Mihajlovic makes his debut on the Sampdoria bench against another of his former clubs, Lazio, and both sides have big changes.
It kicks off at Marassi at 14.00 GMT, click here for a match preview.
Mihajlovic only left his job as Coach of Serbia on Wednesday evening, though Delio Rossi was fired by Samp over a week ago.
The former Catania and Fiorentina boss has to do without suspended striker Eder, while Bartosz Salamon and Gaetano Berardi are injured.
Miha therefore gives Nicola Pozzi and Manolo Gabbiadini rare starts in a new system.
Lazio are struggling in Serie A this season, especially away from home with just three draws and three defeats.
Vladimir Petkovic is under pressure and has lost Miroslav Klose to injury yet again, so switches to a 3-4-3 formation.
Antonio Candreva and youngster Keita Balde fan out around Sergio Floccari for the trident attack, but Hernanes and Lucas Biglia are both dropped.
Sampdoria: Da Costa; Mustafi, Gastaldello, Costa; De Silvestri, Palombo, Obiang, Krsticic, Wszolek; Pozzi, Gabbiadini
Sampdoria bench: Fiorillo, Tozzo, Fornasier, Rodriguez, Regini, Maresca, Poulsen, Renan, Gavazzi, Wsozlek, Bjarnason, Gentsoglou, Petagna
Lazio: Marchetti; Radu, Cana, Ciani; Lulic, Onazi, Ledesma, Konko; Candreva, Floccari, Keita
Lazio bench: Berisha, Strakosha, Cavanda, Novaretti, Pereirinha, Vinicius, Hernanes, Biglia, Gonzalez, Perea, Ederson, Felipe Anderson