Fiorentina have already qualified, but visit Pacos Ferreira to defend their 100 per cent record in the Europa League.
It kicks off in Portugal at 20.05 GMT and Vincenzo Montella rotates the squad, leaving behind Giuseppe Rossi, Borja Valero, Gonzalo Rodriguez and the injured Mario Gomez.
Josip Ilicic gets a rare start and an opportunity to prove himself amid reports of a January exit, partnering Ryder Matos.
Gustavo Munua, Marvin Compper, Marcos Alonso and Marko Bakic also get rare starts, while Massimo Ambrosini returns from injury.
Pacos Ferreira opt for a no-striker system with Ruben Ribeiro as a ‘False 9.’
The hosts have just one point in four games in Group E and changed Coach since the 3-0 defeat in Florence, as Costinha resigned on October 28 to make way for Henrique Calisto.
Pacos Ferreira: Antonio Filipe; Tony, Tiago Valente, Ricardo, Helder Lopes; Anunciaçao, Andre Leao; Manuel José, Seri, Bebé, Ruben Ribeiro
Pacos Ferreira bench: Degra, Gregory, Romeu, Sergio Oliveira, Irobiso, Caetano, Hurtado
Fiorentina: Munua; Roncaglia, Compper, Tomovic, Alonso; Aquilani, Bakic, Ambrosini; Mati Fernandez, Ilicic; Matos
Fiorentina bench: Neto, Savic, Pizarro, Cuadrado, Capezzi, Fazzi, Yakovenko
See the latest Serie A predictions and betting tips with Eurotips.co.uk