Sampdoria have Eder back in the attack as they welcome Udinese, who are fresh from knocking Inter out of the Coppa Italia.
It kicks off at 18.00 GMT, click here for a match preview.
This game has been moved to Monday night due to Udinese’s Coppa Italia commitments, as on Thursday evening they caused a huge upset by eliminating Walter Mazzarri’s Inter.
Luis Muriel is still out injured, but Antonio Di Natale leads the way with his first appearance since announcing he’ll retire at the end of the season.
The veteran is supported by both Roberto Pereyra and Maicosuel in a more attacking line-up than seen recently.
Zeljko Brkic has had problems with his neck over the last few days and skipped several training sessions, so Ivan Kelava takes over in goal.
Sampdoria had ended 2013 unbeaten under Sinisa Mihajlovic, but have now lost two on the bounce between Serie A and the Coppa Italia.
Eder returns from an injury lay-off to play in front of Manolo Gabbiadini and 21-year-old Polish talent Pawol Wszolek, but Pedro Obiang is suspended in midfield.
Udinese have only won five of their last 32 visits to Genoa, the most recent a 3-1 result in 2010.
Sampdoria: Da Costa; De Silvestri, Mustafi, Gastaldello, Costa; Palombo, Krsticic; Gabbiadini, Soriano, Wszolek; Eder
Udinese: Kelava; Heurtaux, Danilo, Domizzi; Basta, Pinzi, Allan, Gabriel Silva; Pereyra, Maicosuel; Di Natale
See the latest Serie A predictions and betting tips with Eurotips.co.uk