Clarence Seedorf takes Milan to the San Paolo tonight, while Fiorentina host Atalanta and Udinese-Chievo is a six-pointer.
It begins this afternoon at 17.00 GMT with two games, Fiorentina-Atalanta and Udinese-Chievo.
At 19.45 GMT Napoli try to get back on track against a Milan side that is also struggling at the moment.
On Sunday the early kick-off is Torino-Bologna, followed by the huge Rome Derby and Juventus away to high-flying Hellas Verona.
Tomorrow evening Walter Mazzarri is looking for his first Inter victory of 2014 against giant-killing Sassuolo.
See the latest Serie A predictions and betting tips with Eurotips.co.uk