The referees have been assigned for Europa League games featuring Juventus, Napoli, Fiorentina and Lazio.
The tournament reaches its knockout phase on Thursday with the first legs of the Round of 32.
Juventus-Trabzonspor will be officiated by Belarus referee Aleksei Kulbakov at 18.00 GMT.
Swansea-Napoli is handed to Croatian Ivan Bebek at 20.05 GMT.
Esbjerg-Fiorentina is under the guidance of Russian official Sergei Karasev at 18.00 GMT.
Lazio’s clash with Bulgarian side Ludogorets is overseen by German referee Felix Zwayer at 20.05 GMT.