Milan have lost Christian Abbiati as well for tomorrow’s trip to Sampdoria, as he is suffering from flu.
The Serie A tie kicks off on Sunday at 14.00 GMT, click here for a match preview.
Clarence Seedorf already had to deal with an extensive injury list, including Mario Balotelli, Mattia De Sciglio, Cristian Zapata, Robinho, Stephan El Shaarawy, Matias Silvestre, Vlater Birsa and Bryan Cristante.
Now goalkeeper Abbiati has also pulled out after coming down with flu symptoms and a high temperature.
It remains to be seen whether Marco Amelia or Gabriel will be picked, though since taking over from Massimiliano Allegri the new Coach has tended to favour Amelia.
Milan squad for Sampdoria: Amelia, Coppola, Gabriel, Abate, Bonera, Constant, Mexes, Rami, Zaccardo, Emanuelson, Essien, De Jong, Honda, Kaka, Montolivo, Muntari, Poli, Saponara, Taarabt, Pazzini, Petagna
See the latest Serie A predictions and betting tips with Eurotips.co.uk