The early kick-off sees a revived Livorno host age-old rivals and Serie A high-flyers Hellas Verona.
It begins at the Stadio Picchi at 11.30 GMT, click here for a match preview.
There is bad blood between the two sets of fans, so fears of crowd trouble pervade the lead-up to this game.
On the field it is an intriguing challenge between a Livorno side that has rediscovered its form after a crisis and Verona who are still very much in the hunt for Europe.
Livorno are fresh from a shock 2-1 victory away to Cagliari that pulled them out of the relegation zone.
Captain Andrea Luci damaged knee ligaments in that game and is out for the rest of the season, while Luca Siligardi and Cristian Piccini are also sidelined for this test.
Federico Ceccherini and Marco Benassi sit out bans for the hosts, but Innocent Emeghara and Paulinho again lead the way in attack.
Ishak Belfodil is only on the bench following his January loan switch from Inter.
Verona have stuttered recently and were beaten by fellow high-flyers Torino last week, losing three of the last five games.
Emil Hallfredsson is suspended in midfield, while Domenico Maietta and Alejandro Gonzalez are sidelined.
This gives Marquinho the chance to shine following his loan from Roma, while Bosko Jankovic completes the trident with Juan Iturbe and Luca Toni.
Both these clubs were promoted from Serie B last summer, though Livorno had to go via the play-offs.
When they met here last season, Hellas emerged with a 2-0 victory.
Livorno: Bardi; Castellini, Rinaudo, Coda; Mesbah, Duncan, Emerson, Greco, Mbaye; Emeghara, Paulinho
Verona: Rafael; Cacciatore, Moras, Marques, Albertazzi; Romulo, Donadel, Marquinho; Iturbe, Toni, Jankovic
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