Napoli shelve squad rotation and start Gonzalo Higuain against Alberto Gilardino’s Genoa tonight.
It kicks off at 20.00 GMT, click here for a match preview.
This tie concludes Serie A Week 25 and Rafa Benitez would usually make huge changes in-between Europa League encounters with Swansea City.
However, he is taking no chances in a tricky fixture and starts Higuain with support from Dries Mertens, Marek Hamsik and Jose Callejon.
Jorginho is cup-tied and Federico Fernandez was suspended on Thursday, so they both start tonight.
Pepe Reina has to go in goal following a season-ending injury for Rafael Cabral at the Liberty Stadium.
Mertens announced to media that Napoli are particularly eager to get a victory “so we can dedicate it to Rafael” ahead of his knee surgery in Brazil.
Genoa are in fine form and can count on veteran hitman Gilardino leading the attack with Moussa Konate and Giuseppe Sculli.
Francelino Matuzalem returns to face his former club, having started his Italian career at the San Paolo in 1999, and Nicolas Burdisso has brought defensive solidity since arriving from Roma in January.
The atmosphere is sure to be celebratory, as the two sets of fans have been twinned for over 30 years and were promoted from Serie B together.
Napoli: Reina; Reveillere, Fernandez, Albiol, Ghoulam; Behrami, Jorginho; Mertens, Hamsik, Callejon; Higuain
Napoli bench: Contini, Colombo, Henrique, Britos, Maggio, Inler, Dzemaili, Radosevic, Insigne, Pandev, Duvan Zapata
Genoa: Perin; Burdisso, De Maio, Antonini; Motta, Matuzalem, Bertolacci, Antonelli; Konate, Gilardino, Sculli
Genoa bench: Bizzarri, Albertoni, Cofie, Marchese, Calaio, Fetfatzidis, Centurion, De Ceglie, Sturaro, Cabral, Portanova
See the latest Serie A predictions and betting tips with Eurotips.co.uk