Roberto Donadoni can further wreck Milan’s season with Parma, while Gian Piero Gasperini’s Genoa aim to hurt Juventus.
Click here for all the individual match previews from Serie A Week 28, plus the report from last night’s Verona-Inter.
The action begins at 11.30 GMT with mid-table tussle Atalanta-Sampdoria.
At 14.00 GMT Milan will face a fan protest after two consecutive Serie A defeats and Champions League elimination, so this is the worst time to welcome Antonio Cassano, Donadoni and sixth-placed Parma.
Lazio also aim to stop their slide in Sardinia, while there are crucial relegation dogfights Livorno-Bologna and Sassuolo-Catania.
There are two fixtures this evening at 19.45 GMT, as Juventus visit their former Primavera Coach Gasperini’s Genoa and Fiorentina host Chievo.
On Monday Napoli try to get back on track after their Europa League defeat to Porto by taking on Torino at 18.00 GMT.
The round is completed tomorrow at 20.00 GMT with Roma-Udinese.
See the latest Serie A predictions and betting tips with Eurotips.co.uk