Leaders Juventus rotate the squad to start Daniel Osvaldo and Marco Storari in their trip to bottom of the table Catania.
It kicks off at the Stadio Massimino at 19.45 GMT, click here for a match preview.
The Bianconeri are running away with the Scudetto and eager to consolidate their 14-point lead, but also have to focus on the Europa League quarter-final against Lyon.
Andrea Pirlo free kicks proved decisive in two consecutive games against Genoa and Fiorentina, but he is given a well-earned rest while Paul Pogba is suspended.
Antonio Conte rotates the squad with Gigi Buffon and Fernando Llorente among those rested, but some decisions are forced upon him.
Andrea Barzagli, Angelo Ogbonna, Claudio Marchisio, Mirko Vucinic and Federico Peluso are sidelined.
Catania are propping up the table and last week threw away a one-goal lead to lose 3-1 in a relegation dogfight at Sassuolo.
Lucas Castro, Sergio Almiron, Nicolas Spolli and Alberto Frison are carrying injuries for the hosts.
Gonzalo Bergessio is their top scorer and the one to watch in attack, flanked by Pablo Barrientos with Francesco Lodi the free kick specialist.
Catania: Andujar; Bellusci, Gyomber, Rolin; Izco, Plasil, Lodi, Rinaudo, Monzon; Bergessio, Barrientos
Catania bench: Capuano, Keko, Boateng, Petkovic, Leto, Ficara, Legrottaglie, Fedato, Pablo Alvarez, Peruzzi, Biraghi
Juventus: Storari; Caceres, Bonucci, Chiellini; Lichtsteiner, Vidal, Pirlo, Padoin, Isla; Tevez, Osvaldo
Juventus bench: Buffon, Rubinho, Romagna, Asamoah, Llorente, Gerbaudo, Giovinco, Quagliarella
See the latest Serie A predictions and betting tips with Eurotips.co.uk