Carlos Tevez, Daniel Osvaldo and Paul Pogba start as Juventus visit Lyon in the Europa League quarter-final.
The first leg kicks off at the Stade de Gerland at 20.05 UK time (19.05 GMT).
Both sides have numerous problems to contend with going into the game.
Lyon are without Milan Bisevac, Gueida Fofana, Miguel Lopes, Mouhamadou Dabo, Clement Grenier and ex-Milan midfielder Yoann Gourcuff.
Samuel Umtiti has passed a late fitness test to start in defence.
Juventus have Angelo Ogbonna, Andrea Barzagli and Federico Peluso injured, while Tevez returns well rested after his Serie A ban ruled him out of the 2-0 defeat to Napoli.
Arturo Vidal is suspended, so Pogba starts with Claudio Marchisio and Andrea Pirlo.
It’s the first time these two clubs have ever played each other in a competitive fixture.
Lyon: Lopes; Tolisso, Koné, Umtiti, Bedimo; Ferri, Gonalons; Malbranque, Lacazette, Mvuemba; Briand
Lyon bench: Vercoutre, Zeffane, Sarr, Danic, Fekir, Gomis, Njie
Juventus: Buffon; Caceres, Bonucci, Chiellini; Isla, Pogba, Pirlo, Marchisio, Asamoah; Tevez, Osvaldo
Juventus bench: Storari, Peluso, Lichtsteiner, Padoin, Vucinic, Giovinco, Llorente
Ref: Collum (SCO)