Ricky Alvarez, Jonathan, Walter Samuel and Rolando are out of Inter’s squad to face Napoli on Saturday.
The Serie A clash kicks off at San Siro tomorrow at 19.45 UK time (18.45 GMT), click here for a match preview.
Alvarez and Jonathan are still sidelined by injury, along with long-term absentee Juan Jesus.
Samuel and Rolando are both suspended, so it is entirely possible Esteban Cambiasso will move into a centre-back role.
Inter squad for Napoli: Handanovic, Carrizo, Castellazzi; Zanetti, Andreolli, Campagnaro, Ranocchia, D’Ambrosio, Nagatomo; Kovacic, Guarin, Kuzmanovic, Cambiasso, Taider, Hernanes; Palacio, Icardi, Botta, Milito