Roma-Juventus is a Serie A showcase, but the Europa League and relegation races are wide open in Atalanta-Milan, Torino-Parma and Bologna-Catania.
Click here for match previews from every single Serie A Week 37 fixture, plus reports on Saturday’s goal-packed Inter-Lazio and Verona-Udinese.
The action begins today at 11.30 UK time (10.30 GMT) with Atalanta-Milan as the Rossoneri continue their Europa League comeback.
This afternoon Torino-Parma is practically a play-off for European qualification, while Livorno-Fiorentina is a Tuscan Derby.
Catania will be relegated unless they win away to Bologna today, while Chievo visit Cagliari and Sassuolo host Genoa.
Sampdoria-Napoli should be entertaining, as both sides are playing only for pride.
At the unusual kick-off time of 16.45 UK time (15.45 GMT), the Stadio Olimpico will host the top two in Serie A this season.
It was going to be a Scudetto showdown, but now it’s a showcase for Italian football as Roma host title winners Juventus.
See the latest Serie A predictions and betting tips with Eurotips.co.uk