Belgium and USA have injuries to contend with as they face off in the last Round of 16 fixture.
It kicks off at 21.00 UK time (20.00 GMT) in Salvador de Bahia, the winners going on to face Argentina.
The Red Devils were considered one of the dark horses for the World Cup, but despite some not entirely convincing performances have been able to win all three group games.
Curiously, all four of their goals so far have been scored in the final 20 minutes.
Belgium and USA have injuries to contend with as they face off in the last Round of 16 fixture.
It kicks off at 21.00 UK time (20.00 GMT) in Salvador de Bahia, the winners going on to face Argentina.
The Red Devils were considered one of the dark horses for the World Cup, but despite some not entirely convincing performances have been able to win all three group games.
Curiously, all four of their goals so far have been scored in the final 20 minutes.
Anthony Vanden Borre is out for the rest of the World Cup after fracturing his fibula, while Thomas Vermaelen is also sidelined.
Captain Vincent Kompany is able to start despite carrying an injury.
Steven Defour is suspended following his red card in the 1-0 victory over South Korea.
Young striker Divock Origi gets his chance up front after impressive substitute appearances.
USA lost their final group game to Germany, but still secured qualification ahead of Cristiano Ronaldo’s Portugal on goal difference.
Jozy Altidore is still on the bench after his hamstring injury kept him out of the last two matches, so Clint Dempsey remains as centre-forward.
Belgium will be glad to note that so far all seven group winners have progressed to the quarter-finals, so they can make it a full house.
Belgium: Courtois; Alderweireld, Van Buyten, Kompany, Vertonghen; Fellaini, Witsel; Mertens, De Bruyne, E Hazard; Origi
USA: Howard; Johnson, Gonzalez, Besler, Beasley; Jones, Cameron, Bradley, Bedoya, Zusi; Dempsey