Nemanja Vidic is expected to start against Manchester United in the same Inter XI that faced Real Madrid at the weekend.
The Nerazzurri continue their tour of the United States with a clash against the Red Devils in Maryland in later tonight.
Walter Mazzarri is expected to name the same starting line-up that began Saturday’s penalty shoot-out win against Real Madrid, meaning Vidic will face up to his old colleagues from kick-off.
It also suggests that whilst Mato Kovacic has shown improvement in recent days on a calf issue, he is unlikely to be risked from the start.
Meanwhile, Louis van Gaal is expected to run with a mixture of youth and experience in his United team, who have netted 10 goals in their two friendlies so far in the US, against LA Galaxy and Roma.
Both managers are set to begin the game fielding formations with three-man defences.
Inter (3-5-2): Handanovic; Ranocchia, Vidic, Juan Jesus; D'Ambrosio, Jonathan, Kuzmanovic, Obi, Dodo; Botta, Icardi
Manchester United (3-4-1-2): Johnstone; Jones, Evans, blackett; Valencia, Cleverley, Herrera, James; Mata; Welbeck, Rooney
See the latest Serie A predictions and betting tips with Eurotips.co.uk