Roberto Mancini reshuffles Inter again as Andrea Stramaccioni and Antonio Di Natale’s Udinese visit San Siro.
It kicks off at 19.45 GMT, click here for a match preview.
The Nerazzurri have stuttered all season and even a victory this evening would only put them in joint eighth place with Fiorentina, while failure to win puts them in the bottom half of the table.
This match is a head-to-head for position, as going in Udinese sit one point ahead of the 2010 Treble winners.
Hernanes and Jonathan are still sidelined, but Yuto Nagatomo and Nemanja Vidic return from injury, though the ex-Manchester United defender is benched.
Mancini reshuffles his pack yet again with a 4-3-3 system, using Rodrigo Palacio, Mauro Icardi and Mateo Kovacic together.
Daniel Osvaldo drops down to the bench despite scoring in last week’s 4-2 defeat to Roma, the first and only loss since Mancio took over from Walter Mazzarri.
Udinese played at San Siro two weeks ago and were beaten 2-0 by Milan, but promised a very different performance and attitude tonight.
Coach Stramaccioni and assistant manager Dejan Stankovic are both very familiar with Inter and will be eager to cause an upset in front of their old fans.
Strama was in charge from March 2012 to June 2013, when he was replaced by Mazzarri.
Luis Muriel is still on the treatment table with Maurizio Domizzi suspended, so Bruno Fernandes supports veteran hitman Di Natale in a new 3-5-1-1 system.
Cyril Thereau and Panagiotis Kone are on the bench ready to come on and change the tactics.
The Friulani are without a win in five Serie A games, managing two draws and three defeats since disposing of Atalanta 2-0 on October 26.
Inter: Handanovic; Nagatomo, Ranocchia, Juan Jesus, Dodò; Guarin, Medel, Kuzmanovic; Palacio, Icardi, Kovacic
Inter bench: Carrizo, Berni, Andreolli, Osvaldo, Campagnaro, Vidic, Obi, Mbaye, D’Ambrosio, Krhin, M’Vila, Bonazzoli
Udinese: Karnezis; Heurtaux, Danilo, Piris; Widmer, Badu, Guilherme, Allan, Pasquale; Fernandes; Di Natale
Udinese bench: Brkic, Scuffet, Wague, Belmonte, Bubnjic, Hallberg, Kone, Gabriel Silva, Pinzi, Thereau, Geijo, Evangelista
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