Juan Camilo Zuniga returns for Napoli against Inter, but Walter Gargano, Christian Maggio and Miguel Britos miss out.
It kicks off at the Stadio San Paolo on Sunday at 19.45 GMT, click here for a match preview.
Zuniga has finally returned to the squad for the first time in five months, while Lorenzo Insigne is also a step closer to making his comeback following knee surgery.
Colombia international Zuniga has not played since the last fixture against Inter, a 2-2 draw on October 19.
However, Gargano’s thigh strain is confirmed and with it 10 to 15 days on the touchline.
Maggio and Britos are out of action too.
Napoli squad for Inter: Rafael, Andujar, Colombo; Mesto, Henrique, Koulibaly, Albiol, Ghoulam, Strinic, Zuniga; Jorginho, David Lopez, Inler, De Guzman; Callejon, Mertens, Gabbiadini, Hamsik, Duvan Zapata, Higuain