Napoli left out transfer-listed Jonathan de Guzman, Edu Vargas and Juan Camilo Zuniga for the trip to Sassuolo.
It kicks off on Sunday at 19.45 UK time (18.45 GMT), click here for a match preview.
The Partenopei are without Faouzi Ghoulam, who sits out a one-match ban, and the injured Mariano Andujar.
Notably left out are De Guzman (who seems ready to turn down a move to Sunderland), Chile international Vargas and Zuniga.
Napoli squad for Sassuolo: Reina, Rafael, Gabriel, Maggio, Hysaj, Henrique, Strinic, Chiriches, Koulibaly, Luperto, Albiol, Valdifiori, Allan, Jorginho, Hamsik, David Lopez, Dezi, El Kaddouri, Mertens, Callejon, Insigne, Gabbiadini, Higuain
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