Lazio medical staff confirm Filip Djordjevic is out against Udinese, but Federico Marchetti returns after a month.
It kicks off at the Stadio Olimpico on Sunday at 17.00 UK time (16.00 GMT). Click here for a match preview.
“Unfortunately, Djordjevic was unable to follow our plans for recovery,” Stefano Salvatori told Lazio Style Radio.
“We were hoping to have him available for the Coach this week, but unfortunately the ankle has still not fully recovered. We’ll have to take it one day at a time.
“There’s positive news for Lucas Biglia, as he’s doing well and is ahead of schedule. Next week we’ll evaluate whether to speed it up and there will be more tests on Tuesday.
“Miroslav Klose is undergoing physiotherapy and next week will go to Germany for more tests.
“We performed some check-ups on Edson Braafheid and Ravel Morrison, but they were purely precautionary just to be on the safe side. They are training and at the disposal of the Coach.
“Federico Marchetti is working and on Sunday it’ll be exactly one month since the rib fracture. He’s been able to move quicker and is available.”