Coach Roberto Mancini reportedly has a list of players to get rid of, including Martin Montoya, Adem Ljajic, Yuto Nagatomo and Danilo D'Ambrosio.
The transfer window doesn't open until January, but the Nerazzurri are believed to have already made up their mind as to who should leave.
According to SportMediaset, Mancini will be dropping Montoya, who didn't see a single minute of playing time so far, as well as Ljajic.
The Serbian joined the Biscione from Roma on loan and would cost €11m to buy in full, but his attitude and his lack of effort so far have not impressed Mancini.
Nagatomo and D'Ambrosio have also been shown scant space. Both had been offered to other teams during the summer but refused to move, and it seems increasingly likely they'll depart in the summer.
Marcelo Brozovic may also go away, while youngsters Assane Gnoukouri and Federico Dimarco could be loaned out to build experience.