Mbaye Niang is in the Milan squad for the first time this season, but Mario Balotelli and Ignazio Abate miss out.
It kicks off on Sunday at 19.45 GMT, click here for a match preview.
Niang had been out of action since early August with a fractured metatarsal, but Coach Sinisa Mihajlovic said he could make his comeback against Lazio for 10-15 minutes.
Mbaye Niang is in the Milan squad for the first time this season, but Mario Balotelli and Ignazio Abate miss out.
It kicks off on Sunday at 19.45 GMT, click here for a match preview.
Niang had been out of action since early August with a fractured metatarsal, but Coach Sinisa Mihajlovic said he could make his comeback against Lazio for 10-15 minutes.
Balotelli is still unavailable due to a sports hernia, while Abate and long-term absentee Jeremy Menez are also on the treatment table.
Milan squad for Lazio: Abbiati, Donnarumma, Diego Lopez; Alex, Antonelli, Calabria, De Sciglio, Rodrigo Ely, Mexes, Romagnoli, Zapata; Bertolacci, Bonaventura, De Jong, Josè Mauri, Kucka, Montolivo, Poli, Suso; Bacca, Cerci, Honda, Luiz Adriano, Niang