We could end the night with three Serie A leaders, as Fiorentina host Frosinone and Napoli visit Genoa before a huge Lazio-Milan.
The lunchtime game sees Fiorentina take on high-flying new boys Frosinone and a victory would put the Viola joint top with Inter.
Napoli aim to continue their seemingly unstoppable form away to Gian Piero Gasperini’s Genoa and could also join the Nerazzurri looking down on the rest of Serie A.
Sassuolo visit Udinese and Carpi welcome Verona in a relegation dogfight. Roberto Donadoni makes his Bologna debut against Atalanta, who are fresh from defeating Lazio.
Tonight there’s another fascinating encounter at the Stadio Olimpico between Lazio and Milan, two sides who can be completely unpredictable.
The round concludes on Monday with Chievo-Sampdoria and Palermo-Empoli.
See the latest Serie A predictions and betting tips with Eurotips.co.uk