Sampdoria face Lazio without Eder, while Felipe Anderson is on the bench for the hosts.
Both sides go into this game in poor form, with Sampdoria’s six-game winless run already having cost Coach Walter Zenga his job, with Vincenzo Montella coming in.
Meanwhile, the Biancocelesti haven’t won a Serie A match since beating Torino on October 25, with reports Stefano Pioli is under pressure.
Italian international Eder reportedly pulled out of training this morning with a muscular problem, and is not included in the Blucerchiati’s starting line-up.
Antonio Cassano starts alongside Lazaros Christodoulopoulos and Carlos Carbonero, with Luis Muriel on the bench.
For the home side, Pioli has opted not to include Felipe Anderson, with Antonio Candreva supporting Miroslav Klose and Filip Djordjevic up-front.
Lazio: Marchetti; Konko, Hoedt, Gentiletti, Radu; Cataldi, Biglia, Parolo; Candreva; Djordjevic, Klose
Lazio bench: Berisha, Guerrieri, Braafheid, Prce, Patric, Onazi, Felipe Anderson, Oikonomidis, Morrison, Milinkovic, Mauri, Matri
Sampdoria: Viviano; De Silvestri, Moisander, Zukanovic, Regini; Fernando, Barreto Soriano; Carbonero, Cassano, Christodoulopoulos
Sampdoria bench: Puggioni, Cassani, Coda, Rodriguez, Correa, Pereira, Palombo, Ivan, Rocca, Bonazzoli, Muriel