Napoli started 2016 just one point off leaders Inter and host a Torino side in trouble.
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The Partenopei ended the year with a 3-1 victory away to Atalanta, a place in the Coppa Italia quarter-finals and a 100 per cent record in the Europa League group stage.
Under Maurizio Sarri they have lost only twice all season, one being the opener at Sassuolo and the other 3-2 at Bologna on December 6.
Some changes are forced tonight, as Jorginho is suspended, so Mirko Valdifiori steps in to the midfield berth.
Gonzalo Higuain leads the usual line-up with Jose Callejon, Lorenzo Insigne and Marek Hamsik.
Toro fans are protesting after a poor run of results, above all the 4-0 Coppa Italia thrashing to rivals Juventus and a 1-0 home defeat to Udinese.
Ex-Napoli striker Fabio Quagliarella and Andrea Belotti spearhead the attack with Joel Obi unavailable.
Toro have only conquered the Stadio San Paolo eight times in 61 Serie A visits, the most recent being 2-1 in May 2009.
Napoli: Reina; Hysaj, Albiol, Koulibaly, Ghoulam; David Lopez, Valdifiori, Hamsik; Callejon, Higuain, Insigne
Napoli bench: Gabriel, Rafael, Strinic, Allan, Maggio, Mertens, Dezi, Chiriches, Gabbiadini, El Kaddouri, Chalobah, Luperto
Torino: Padelli; Bovo, Glik, Moretti; Peres, Acquah, Vives, Baselli, Molinaro; Quagliarella, Belotti
Torino bench: Castellazzi, Ichazo, Zappacosta, Maxi Lopez, Gazzi, Benassi, Martinez, Jansson, Silva, Prcic, Pryyma
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