Rudi Garcia and Sinisa Mihajlovic know their jobs are on the line, but Mohamed Salah is on the bench for Roma-Milan.
It kicks off at the Stadio Olimpico at 19.45 GMT, follow the action as it happens on our LIVEBLOG.
This could well be the final curtain for one or even both Coaches, depending on the result, as they are in dire straits.
Garcia seems to be more solid despite winning just one of his last nine competitive games and throwing away a 3-1 lead to draw 3-3 at Chievo on Wednesday.
Mihajlovic is truly hanging by a thread following a 1-0 home defeat to Bologna and even if he wins tonight, there’s next week’s Coppa Italia quarter-final with Carpi.
Edin Dzeko is still suspended after the appeal against a two-match ban for insulting the referee was rejected, while Seydou Keita and Salih Ucan miss out.
Miralem Pjanic and Radja Nainggolan are back from bans, while Francesco Totti makes his first appearance on the bench in three months.
Daniele De Rossi and Mohamed Salah were at risk with injury concerns, but the Egypt international is benched in favour of 18-year-old striker Umar Sadiq.
The Nigerian teenager has scored in each of his last two Serie A appearances, including his first start against Chievo.
Milan are still without long-term absentees Mario Balotelli, Jeremy Menez and Diego Lopez, while Alex has also been ruled out of this trip.
Alessio Cerci was left behind pending a transfer, especially after he was caught in a casino at 2am after the defeat to Bologna.
Carlos Bacca and Luiz Adriano lead the way, but Cristian Zapata gets the nod in defence in place of ex-Roma man Philippe Mexes.
Alessio Romagnoli and Andrea Bertolacci also take on their former club for the first time.
Milan have won just one of their last six meetings with Roma, home and away, a 2-1 result at San Siro in May 2015.
Their most recent victory at the Olimpico was a 3-2 thriller in October 2011.
Roma: Szczesny; Florenzi, Manolas, Rudiger, Digne; Pjanic, De Rossi, Nainggolan; Gervinho, Sadiq, Iago Falque
Roma bench: De Sanctis, Lobont, Gyomber, Castan, Maicon, Torosidis, Emerson, Vainqueur, Machin, Di Livio, Tumminello, Totti, Salah
Milan: Donnarumma; Abate, Zapata, Romagnoli, De Sciglio; Honda, Kucka, Bertolacci, Bonaventura; Luiz Adriano, Bacca
Milan bench: Abbiati, Calabria, Antonelli, Mexes, Montolivo, De Jong, Boateng, Mauri, Poli, Nocerino, Niang
See the latest Serie A predictions and betting tips with Eurotips.co.uk