Milan are again called to save Sinisa Mihajlovic’s job and Fiorentina can leapfrog Inter into third place.
It kicks off at San Siro at 19.45 GMT, follow the action as it happens on our LIVEBLOG.
Despite beating Carpi to reach the Coppa Italia semi-final this week and ending Rudi Garcia’s reign with a 1-1 at Roma, Mihajlovic remains on the chopping block.
The Coach joked he’d been to so many Last Chance Saloons that he never wanted to see a bar again, but here faces his former club.
Philippe Mexes, Jeremy Menez, Diego Lopez and Rodrigo Ely miss out for the hosts, who use Mbaye Niang with Carlos Bacca upfront.
Keisuke Honda and Jack Bonaventura again take the wide roles in midfield.
Fiorentina are without Milan Badelj and the suspended Gonzalo Rodriguez, so Coach Paulo Sousa is forced into changes.
Nenad Tomovic steps in to defence with Federico Bernardeschi returning from his ban to partner Borja Valero. Mario Suarez is a surprise starter in midfield.
Nikola Kalinic scored a hat-trick in this stadium when beating Inter 4-1, so is hoping for more of the same, supported by Josip Ilicic and Borja Valero.
Milan: Donnarumma; Abate, Alex, Romagnoli, Antonelli; Honda, Montolivo, Bertolacci, Bonaventura; Niang, Bacca
Milan bench: Abbiati, Livieri, De Sciglio, Calabria, Simic, Zapata, De Jong, Poli, Kucka, Jose Mauri, Boateng, Balotelli
Fiorentina: Tatarusanu; Roncaglia, Tomovic, Astori; Bernardeschi, Mario Suarez, Vecino, Alonso; Ilicic, Borja Valero; Kalinic
Fiorentina bench: Sepe, Lezzerini, Gilberto, Pasqual, Blaszczykowski, Mati Fernandez, Verdù, Rossi, Babacar, Baez
See the latest Serie A predictions and betting tips with Eurotips.co.uk