Roma throw Stephan El Shaarawy and Ervin Zukanovic straight into the starting XI against Frosinone in the local derby.
It kicks off at the Stadio Olimpico at 19.45 GMT, follow the action as it happens on our LIVEBLOG.
Luciano Spalletti is still looking for his first win on the Giallorossi bench after a 1-1 draw with bottom club Hellas Verona and defeat at Juventus.
Roma throw Stephan El Shaarawy and Ervin Zukanovic straight into the starting XI against Frosinone in the local derby.
It kicks off at the Stadio Olimpico at 19.45 GMT, follow the action as it happens on our LIVEBLOG.
Luciano Spalletti is still looking for his first win on the Giallorossi bench after a 1-1 draw with bottom club Hellas Verona and defeat at Juventus.
He has to completely revamp his line-up for this game, as Alessandro Florenzi, Vasilis Torosidis, Lucas Digne, Iago Falque and Kevin Strootman are out of action.
That means new buy El Shaarawy is thrown straight into the thick of the action just days after he arrived from Milan via Monaco.
He hopes to inspire both himself and the misfiring duo Edin Dzeko and Mohamed Salah.
The three-man defence has seemingly been abandoned for a 4-3-3, though Daniele De Rossi is still used as a centre-back.
Another January signing, ex-Sampdoria defender Ervin Zukanovic, starts in defence.
Frosinone are in dire straits during their first ever Serie A campaign and need a huge boost, especially away from home.
Mirko Gori is suspended, while Max Carlini, Roberto Crivello, Oliver Kragl, Aleksandar Tonev and Samuele Longo are injured.
The Canarini haven’t won a Serie A match for two months and have slipped to penultimate place.
Roma’s form isn’t much better, winning only one of the last 13 competitive matches.
Roma: Szczesny; Rudiger, Manolas, De Rossi, Zukanovic; Pjanic, Keita, Nainggolan; Salah, Dzeko, El Shaarawy
Frosinone: Leali; Rosi, Ajeti, Blanchard, Pavlovic; Sammarco, Chibsah, Frara; Dionisi, D Ciofani, Soddimo