Eder is thrown straight into the starting XI for his Inter debut, the Derby della Madonnina against Carlos Bacca’s Milan.
It kicks off at a packed out San Siro this evening at 19.45 GMT. Follow the build-up and action on our LIVEBLOG.
The Nerazzurri were top of the table over the Christmas break, but have plummeted down the standings with just five points from the last five rounds.
They lost at home to Lazio and Sassuolo, were pegged back by Atalanta and Carpi with a barely deserved 1-0 victory away to Empoli the only bright light.
Inter were also humiliated 3-0 by Juventus on Wednesday night in the Coppa Italia semi-final first leg, so the pressure is piling up on Roberto Mancini.
Fredy Guarin has gone to China for Shanghai Shenhua, but Eder was brought in from Sampdoria this week and makes his debut straight away.
He’s in supporting trident with Ivan Perisic and Adem Ljajic fanning out behind Stevan Jovetic.
Jonathan Biabiany is struggling with flu symptoms, but it’s a big decision to drop Mauro Icardi for this huge game.
Felipe Melo is also dropped in favour of a two-man midfield with Gary Medel and the more creative Marcelo Brozovic.
Milan have to do without Luiz Adriano, Philippe Mexes, Rodrigo Ely and Diego Lopez.
Nigel de Jong and Antonio Nocerino are in advanced negotiations for transfer to MLS.
It means M’Baye Niang, who had been on the verge of a move to Leicester City this week, partners on-form Bacca.
16-year-old Gianluigi Donnarumma makes history as the youngest ever goalkeeper to take part in the Milan Derby.
The Rossoneri haven’t won the Derby della Madonnina since a 1-0 result in May 2014, followed by two draws and a defeat.
It’s safe to say these games tend to be tight. There have been just eight goals in the last seven editions.
Inter have lost only one of the last nine encounters with their cousins, winning five.
Milan: Donnarumma; Abate, Alex, Romagnoli, Antonelli; Honda, Montolivo, Kucka, Bonaventura; Niang, Bacca
Milan bench: Abbiati, Livieri, De Sciglio, Calabria, Simic, Zapata, Bertolacci, José Mauri, Poli, Balotelli, Boateng, Menez
Inter: Handanovic; Santon, Miranda, Murillo, Juan Jesus; Brozovic, Medel; Perisic, Eder, Ljajic; Jovetic
Inter bench: Carrizo, Berni, Kondogbia, Palacio, Icardi, Telles, Gnoukouri, D’Ambrosio, Nagatomo, Melo, Manaj
See the latest Serie A predictions and betting tips with Eurotips.co.uk