Empoli aim to end their five-match winless streak against Frosinone and look to Riccardo Saponara and Massimo Maccarone.
It kicks off at 14.00 GMT, click here for a match preview.
The Tuscans are still comfortably mid-table and put in impressive performances, but results have fallen away recently.
Vincent Laurini is suspended with Andrea Costa and Daniele Croce on the treatment table.
Empoli aim to end their five-match winless streak against Frosinone and look to Riccardo Saponara and Massimo Maccarone.
It kicks off at 14.00 GMT, click here for a match preview.
The Tuscans are still comfortably mid-table and put in impressive performances, but results have fallen away recently.
Vincent Laurini is suspended with Andrea Costa and Daniele Croce on the treatment table.
Manuel Pucciarelli is given the nod to partner Maccarone with support from star trequartista Saponara, while Piotr Zielinski and Leandro Paredes are also crucial creative figures in midfield.
Frosinone have a full squad to choose from and are in dire need of a boost to maintain their Serie A status beyond this historic campaign.
Daniel Ciofani and Federico Dionisi lead the 4-3-3 system in attack.
When these sides met in September, Frosinone ran out 2-0 winners thanks to a Dionisi brace.
The Romans have never won away to Empoli, managing a Serie B draw in 2009 and two consecutive defeats.
Empoli: Skorupski; Zambelli, Ariaudo, Tonelli, Mario Rui; Zielinski, Paredes, Buchel; Saponara; Maccarone, Pucciarelli
Frosinone: Leali; Rosi, Russo, Blanchard, Pavlovic; Gori, Frara, Sammarco; Tonev, Dionisi, D Ciofani