Lazio have a very good chance of qualifying for the Europa League Round of 16 as they host Galatasaray.
It kicks off at the Stadio Olimpico at 18.00 GMT, follow the action from this game, Napoli-Villarreal and Tottenham-Fiorentina on our LIVEBLOG.
The first leg ended 1-1 in Istanbul, so the Aquile have an away goal and could progress even with a goalless draw.
Lazio have a very good chance of qualifying for the Europa League Round of 16 as they host Galatasaray.
It kicks off at the Stadio Olimpico at 18.00 GMT, follow the action from this game, Napoli-Villarreal and Tottenham-Fiorentina on our LIVEBLOG.
The first leg ended 1-1 in Istanbul, so the Aquile have an away goal and could progress even with a goalless draw.
Keita Balde Diao sits out a ban, joining the injured Stefan de Vrij, Ricardo Kishna, Santiago Gentiletti and Ravel Morrison.
Alessandro Matri leads the front three with support from Felipe Anderson and Senad Lulic.
Sergej Milinkovic-Savic scored in Turkey and he’ll be one to watch in midfield.
Galatasaray have quite a few problems at the moment and there are reports Coach Mustafa Denizli could get fired.
He was accused of being too defensive in the first leg, but despite expectations does not return Umit Bulut to the centre-forward role, instead keeping Lukas Podolski up there with support from Wesley Sneidjer.
Their star striker, Burak Yilmaz, is the latest player to complete a big money move to China, while Hamit Altintop and Sinan Gumus miss out.
It is a return to the Olimpico for ex-Lazio goalkeeper Fernando Muslera.
Galatasaray managed just two draws and nine defeats since their most last European away victory at Schalke in March 2013.
There has been some tension in the build-up, as Galatasaray fans with flares, paper bombs and fireworks marched through Piazza del Popolo and got into scuffles with police, but they were successfully placed on buses to take them to the Stadio Olimpico.
Lazio: Marchetti; Konko, Mauricio, Bisevac, Radu; Milinkovic-Savic, Biglia, Parolo; Felipe Anderson, Matri, Lulic
Lazio bench: Berisha, Hoedt, Basta, Cataldi, Mauri, Candreva, Klose
Galatasaray: Muslera; Sabri Sarioglu, Denayer, Hakan Balta, Carole; Donk, Chedjou; Öztekin, Selcuk Inan, Sneijder; Podolski
Galatasaray bench: Cenk, Semih Kaya, Bilal Kisa, Olcan Adin, Umit Bulut, Jose Rodriguez
Ref: Bezborodov (RUS)