Antonio Rudiger and Daniele De Rossi are out of Roma’s Champions League trip to Real Madrid.
It kicks off on Tuesday at 19.45 GMT and is the second leg in the Round of 16.
Real Madrid won the first meeting 2-0 at the Stadio Olimpico.
Rudiger has not made the trip due to a right thigh problem, although the extent of the damage will be evaluated tomorrow.
De Rossi is also still out of action with another muscular issue.
Roma squad for Real Madrid: Digne, Nainggolan, Castan, Perotti, Dzeko, Totti, Salah, Maicon, Iago Falque, Pjanic, Keita, Vainqueur, El Shaarawy, Florenzi, Szczesny, De Sanctis, Torosidis, Manolas, Ucan, Pop, Zukanovic