Cristian Brocchi makes his Milan debut without Luiz Adriano, but Juraj Kucka returns against Sampdoria.
It kicks off on Sunday at 19.45 UK time (18.45 GMT), click here for a match preview.
Luiz Adriano didn’t complete today’s training session and is therefore not risked for the trip to Genoa.
M’Baye Niang also misses out on a long-term injury following his car accident.
Milan squad for Sampdoria: Abbiati, Donnarumma, Diego Lopez; Abate, Alex, Antonelli, Calabria, De Sciglio, Mexes, Romagnoli, Zapata; Bertolacci, Bonaventura, Honda, Jose Mauri, Kucka, Locatelli, Montolivo, Poli; Bacca, Balotelli, Boateng, Menez