Juventus have won the Scudetto, but want to continue shattering records and host a Carpi side desperate to avoid relegation.
It kicks off in Turin at 11.30 UK time (10.30 GMT), click here for a match preview.
The Bianconeri were crowned Champions of Italy for the fifth consecutive time this week, able to celebrate at their training centre after watching Napoli lose 1-0 at Roma on Monday afternoon.
Having won 24 of the last 25 games, pausing only to draw at Bologna, Max Allegri was at pains to keep his men focused amid the party atmosphere.
Carpi certainly will be concentrated, as they are hovering three points above the relegation zone and fear Palermo and Frosinone can catch them.
Claudio Marchisio, Giorgio Chiellini, Martin Caceres and Norberto Neto are injured.
Patrice Evra is tested out in a back three, while Hernanes gets a central midfield role.
Leonardo Bonucci starts on the day of his 29th birthday and Paulo Dybala is rested in favour of Alvaro Morata.
Carpi have made a remarkable comeback of their own, as they seemed destined for the drop only a few weeks ago.
Coach Fabrizio Castori is forced to do without suspended Lorenzo Lollo and Raffaele Bianco.
The minnows are unbeaten in three rounds, picking up seven points against Genoa, Milan and Empoli.
The only previous meeting between these sides was an unexpectedly tight 3-2 thriller won by Juventus on December 20.
That game remains long in the memory thanks to Allegri tearing off his coat in a rage at the huge risk his team ran in the final minutes, when Carpi missed a sitter.
Juventus: Buffon; Rugani, Bonucci, Evra; Hernanes, Asamoah, Cuadrado, Pogba, Alex Sandro; Mandzukic, Morata
Carpi: Belec; Zaccardo, Romagnoli, Suagher; Sabelli, Crimi, Cofie, Martinho, Gagliolo; Verdi; Mbakogu