Mohamed Salah returns to face his former club as Fiorentina and Roma reignite their growing rivalry.
It kicks off at the Stadio Franchi at 19.45 UK time (18.45 GMT), follow the build-up and action on our LIVEBLOG.
The Viola are looking for a boost after their 0-0 midweek draw with PAOK Salonika and the trip to Genoa abandoned 28 minutes in due to a hailstorm. The remaining 62 minutes of that game will be played in December.
Paulo Sousa has a full squad to choose from, but drops Federico Bernardeschi after complaining he needed to “think about the team and clear his ideas.”
Nikola Kalinic leads the attack with support from Borja Valero, who was desperately wanted by Roma this summer, and Josip Ilicic.
Roma are under pressure and Coach Luciano Spalletti vented his frustration at reporters during yesterday’s Press conference, suggesting they were “using Francesco Totti to divide” people.
Il Capitano is again on the bench and the Giallorossi have been shaky, coming back from 2-1 down to beat Sampdoria 3-2 with a last-gasp Totti penalty and drawing 1-1 at Viktoria Plzen in the Europa League.
Thomas Vermaelen is on the treatment table along with Antonio Rudiger and Mario Rui, but Juan Jesus is dropped after a costly error midweek.
Edin Dzeko returns to the starting XI with ex-Viola star Salah and Diego Perotti.
These sides faced off repeatedly in the Coppa Italia and Europa League in 2014-15, both of which saw Fiorentina progress.
Fiorentina: Tatarusanu, Tomovic, Gonzalo, Astori, Tello, Sanchez, Badelj, Milic, Ilicic, Borja Valero, Kalinic
Fiorentina bench: Lezzerini, Dragowski, De Maio, Salcedo, Diks, Olivera, Cristoforo, Chiesa, Babacar, Bernardeschi, Zarate
Roma: Szczensny, Florenzi, Manolas, Fazio, Peres, Nainggolan, De Rossi, Strootman, Perotti, Salah, Dzeko
Roma bench: Alisson, Lobont, Jesus, Seck, Emerson, El Shaarawy, Paredes, Gerson, Iturbe, Totti