Milan return Carlos Bacca and Juraj Kucka to the starting XI as they host a Lazio side who lost goalkeeper Federico Marchetti.
It kicks off at 19.45 UK time (18.45 GMT), follow the build-up and action on the LIVEBLOG.
The Rossoneri got back on track in Friday’s 1-0 victory at Sampdoria, although Bacca had to come off the bench to seal it following his training ground row with Coach Vincenzo Montella.
The Colombian returns to the starting XI tonight, moving Gianluca Lapadula to the bench, while Kucka is back after his two-match ban for insulting the referee.
Luca Antonelli is on the treatment table with Andrea Bertolacci, Mati Fernandez and Cristian Zapata, but Mattia De Sciglio returns.
Jack Bonaventura was expected to rest, but Jose Ernesto Sosa's back problem has put paid to that.
Lazio must do without their captain Lucas Biglia due to a muscular problem, along with Ricardo Kishna and exile Ravel Morrison.
Felipe Anderson is bumped to the bench after a series of games and the Rio Olympics, so Sergej Milinkovic-Savic has the trequartista role in a 3-4-1-2 system behind Ciro Immobile and Filip Djordjevic.
Federico Marchetti had a calf problem earlier today, had originally been named in the starting XI, but in the warm-up was nowhere to be seen, so 21-year-old Albanian Thomas Strakosha gets his Serie A debut in goal.
Lazio haven’t won here in Serie A since a Paolo Maldini own goal in September 1989, managing just 11 draws and 15 defeats.
Milan: Donnarumma; Calabria, Paletta, Romagnoli, De Sciglio; Kucka, Montolivo, Bonaventura; Suso, Bacca, Niang
Milan bench: Gabriel, Plizzari, Ely, Vangioni, Gomez, Abate, Locatelli, Sosa, Pasalic, Poli, Honda, Luiz Adriano, Lapadula
Lazio: Strakosha; Bastos, De Vrij, Radu; Basta, Parolo, Cataldi, Lulic; Milinkovic; Djordjevic, Immobile
Lazio bench: Vargic, Marchetti, Hoedt, Wallace, Patric, Lukaku, Murgia, Leitner, Luis Alberto, Lombardi, Felipe Anderson, Keita