Maurizio Sarri could be planning a tactical revolution, as Dries Mertens was used as a centre-forward in training ahead of Napoli-Roma.
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Arkadiusz Milik ruptured his anterior cruciate ligament on international duty and is therefore out of action for four to six months.
Manolo Gabbiadini is expected to lead the attack this weekend, but there are other options.
It had been rumoured Sarri would use Jose Callejon as a False 9, flanked by both Lorenzo Insigne and Mertens.
However, Sky Sport Italia today claim that Napoli tested Belgium international Mertens in the centre-forward role.
The diminutive 29-year-old certainly has a good scoring record, netting four with three assists in just eight competitive appearances this season.
It would be a new and intriguing role for Mertens, confirming Sarri’s 4-3-3 system with a very different strategy – fewer crosses, more rapid passing.
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