Claudio Marchisio is back in the Juventus squad after six months and joined by teenage sensation Moise Kean, but not Leonardo Bonucci.
The match with Udinese kicks off on Saturday at 19.45 UK time (18.45 GMT), click here for a match preview.
Marchisio made his comeback in a friendly test this week and even scored a goal, so is included for the first time since rupturing his anterior cruciate ligament in April.
Another new addition is 16-year-old striker Kean, who has been on absolutely stunning form for the Primavera youth team.
Giorgio Chiellini is included after leaving international duty with a bruised calf, but Leonardo Bonucci and Dani Alves are “rested.”
Bonucci was given two days off this week to be with his family.
Juventus squad for Udinese: Buffon, Chiellini, Benatia, Pjanic, Khedira, Cuadrado, Marchisio, Higuain, Hernanes, Alex Sandro, Mattiello, Barzagli, Mandzukic, Lemina, Dybala, Neto, Lichtsteiner, Sturaro, Audero, Evra, Kean