There are reports Stefano Pioli could drop Ever Banega and use Gary Medel as a centre-back when Inter take on Milan.
The Derby della Madonnina kicks off on Sunday at 19.45 GMT, click here for a match preview.
The only absentee is believed to be Rodrigo Palacio, but new Coach Pioli could make some surprise changes for his Nerazzurri debut.
Ever Banega seems likely to be dropped to the bench in favour of Marcelo Brozovic, who bagged a brace for Croatia midweek.
It seems to be a 4-3-3 formation that Pioli has in mind, although he took great pains to shield the training sessions from view, using large structures and even sheets to block off any vantage points.
Sky Sport Italia suggest Jeison Murillo could be rested after returning from international duty in Colombia, instead using Chilean Medel in central defence alongside Joao Miranda.
It is not an unusual role for Medel, who plays there at international level, but at Inter he has almost always played in midfield.
This is Medel’s comeback game after a three-match ban for lashing out an elbow at Atalanta’s Jasmin Kurtic.
Inter (probable): Handanovic; D’Ambrosio, Miranda, Medel, Ansaldi; Brozovic, Kondogbia, Joao Mario; Candreva, Icardi, Perisic
Inter squad for Milan: Handanovic, Carrizo, Berni; Ansaldi, Ranocchia, Santon, Murillo, Miranda, D'Ambrosio, Nagatomo; Melo, Joao Mario, Kondogbia, Banega, Gnoukouri, Brozovic, Medel; Icardi, Jovetic, Biabiany, Eder, Perisic, Candreva, Gabriel Barbosa