The latest reports suggest Alessio Romagnoli has failed a fitness test and will not feature in tonight’s Milan-Inter clash.
It kicks off at 19.45 GMT, click here for a match preview.
The centre-back had been initially ruled out by a muscular problem during Tuesday’s 0-0 international friendly draw between Italy and Germany.
Yesterday he took part in training, fuelling rumours he could be available after all with a lightning recovery.
However, according to Sky Sport Italia, the verdict from this morning’s fitness test was not good.
Romagnoli won’t be risked, as a relapse could keep him out for several weeks, so Gustavo Gomez is the hot favourite to take his place.
Cristian Zapata remains an outside bet, having not made a single competitive appearance since undergoing ankle surgery in April.
Meanwhile, pundits are increasingly confident Inter will use Gary Medel in central defence, introducing Geoffrey Kondogbia to the midfield.
This is because Jeison Murillo had a nightmare performance for Colombia against Argentina this week.
Milan (probable): Donnarumma; Abate, Paletta, Gomez, De Sciglio; Kucka, Locatelli, Bonaventura; Suso, Bacca, Niang
Inter (probable): Handanovic; D’Ambrosio, Miranda, Medel, Ansaldi; Kondogbia, Joao Mario, Brozovic; Candreva, Icardi, Perisic
See the latest Serie A predictions and betting tips with Eurotips.co.uk