Roma start Francesco Totti, Diego Perotti and Stephan El Shaarawy as they host Cesena in the Coppa Italia quarter-final tonight.
It kicks off at the Stadio Olimpico at 20.00 GMT and the winners go on to face Lazio.
The other semi-final, which is played over two legs, will be between Juventus and Napoli.
Luciano Spalletti makes a few changes to the Giallorossi, but keeps up the quality level with captain Totti getting a rare start in the False 9 role.
Roma start Francesco Totti, Diego Perotti and Stephan El Shaarawy as they host Cesena in the Coppa Italia quarter-final tonight.
It kicks off at the Stadio Olimpico at 20.00 GMT and the winners go on to face Lazio.
The other semi-final, which is played over two legs, will be between Juventus and Napoli.
Luciano Spalletti makes a few changes to the Giallorossi, but keeps up the quality level with captain Totti getting a rare start in the False 9 role.
In fact, the 40-year-old legend has not started a game since December 8 in the Europa League against Astra Giurgiu.
He’s flanked by Perotti and El Shaarawy. Clement Grenier cannot even sit on the bench after his move from Lyon, as the international transfer hasn't come through yet.
After transfer speculation, Leandro Paredes is in midfield, while Mario Rui and goalkeeper Alisson step into the side.
Mohamed Salah is taking part in the Africa Cup of Nations semi-final with Egypt this evening.
Cesena are the only Serie B team still in the Coppa Italia.
They eliminated Empoli and Sassuolo with 2-1 away victories on their way to the quarter-finals.
The men to watch are ex-Cagliari striker Andrea Cocco and marauding wingers Karim Laribi and Francesco Renzetti.
They are missing injured Michael Agazzi, Daniele Capelli and Emmanuel Cascione.
Roma: Alisson; Rudiger, Manolas, Juan Jesus; Bruno Peres, Paredes, Strootman, Mario Rui; Perotti, El Shaarawy; Totti
Roma bench: Szczesny, Lobont, Nainggolan, Dzeko, Vermaelen, De Rossi, Fazio, Gerson, Emerson Palmieri
Cesena: Agliardi; Perticone, Rigione, Ligi; Laribi, Balzano, Kone, Setola, Vitale, Renzetti; Ciano, Rodriguez