Both sides have a lot at stake in the final round, as Cagliari risk relegation and Atalanta need to book their Europa League spot.
Chievo could join Benevento in Serie B if they fail to defeat them in the final game of the season.
Genoa and Torino have both been mired in mid-table for a while now and see out the season at Marassi.
Gianluigi Buffon and Stephan Lichtsteiner waved goodbye to Juventus with a 2-1 victory over relegated Hellas Verona.
It is the most important game of the season for both sides, as Inter need a win to knock Lazio out of the Champions League spot.
Milan are in the Europa League and Fiorentina are practically out of the running, but Atalanta threaten to snatch the precious sixth place.
This southern derby may be a dead rubber for Serie A runners-up Napoli, but Crotone need at least a point to give themselves a shot at survival.
Eusebio Di Francesco concludes an excellent Roma campaign by visiting his former club, who have secured safety.
SPAL vs Sampdoria will be one to watch, as the hosts have their fate in their own hands going into this game level on points with 18th place Crotone.
Udinese finally ended their 14-round negative streak, but need to finish the job against Bologna to secure safety.