Sampdoria got the better of Bologna, thanks to goals from Roberto Soriano and Eder after a red card for the visitors.
The match was called off yesterday after storms in Genoa, and so took place tonight instead.
Italian international Destro led line for the visitors in a 4-2-3-1 formation, with Franco Brienza, Anthony Mounier and Emmanuele Giaccherini in support.
Sampdoria Coach Walter Zenga stuck with his tried-and-tested front-two of Eder and Luis Muriel, with Roberto Soriano just in behind in a 4-3-1-2 system.
The first chance of the game went to the Rossoblu, Brienza’s ninth-minute strike curling over the wall, but clipping the crossbar of Emiliano Viviano’s goal.
Mattia Cassani’s evening lasted just 21 minutes, the full-back being replaced by Pedro Pereira after injury.
Italy CT Antonio Conte was in the stands, and Azzurri international Eder was looking dangerous, picking up possession in wide areas and running at the defence.
Giaccherini was making his Bologna debut, having been frozen out at Sunderland, and was perhaps affected by a lack of game-time. The former Juventus winger pulled up with a groin injury on 26 minutes, and had to be replaced by Luca Rizzo.
The game was struggling to burst into life on a boggy pitch, with Destro in particular being unable to keep hold of the ball.
The second half did not see an immediate improvement, with Samp bossing possession, but failing to offer a cutting edge. Indeed, the Blucerchiati’s first corner of the match came with an hour played.
Eder struck a fierce right-footed shot which Antonio Mirante produced a stunning save to palm over the bar, and Soriano hit the bar from the resulting corner, though he was offside.
That seemed to strike the game into life, and with Rizzo sent off for a second booking on 62 minutes, the hosts started to play with a bit more purpose.
Luis Muriel then created a fantastic chance to break the deadlock, nutmegging a Rossublu defender before dragging his finish wide when one-on-one with Viviano.
The Blucerchiati finally took the lead with 15 minutes to play, Eder exchanging passes with Muriel before firing the ball in via the post.
Soriano then showed why Milan and Napoli had been interested in his signature this summer, with a fantastic second goal.
Substitute Joaquin Correa beat two players with a mazy run, before laying it inside for the Italian. The midfielder looked up before smashing a thunderous strike into the top corner.
Rossoblu captain Luca Rossettini was injured trying in the move, but could not come off with all three substitutions made.
That saw several stoppages to play, as Rossettini fell to the turf clutching at his calf, his side now effectively playing with nine men.
Brienza almost pulled one back in the third minute of stoppage time, but Viviano did well to tip it over the bar.
See the latest Serie A predictions and betting tips with Eurotips.co.uk
Sent off: Rizzo 62 (B)