Bologna plays host to resurgent Genoa in a mid-table clash that could spur the rest of the campaign in both a positive or negative direction for each club.
Following their Europa League exit, Napoli must now concentrate their whole attention to securing the Scudetto, and their first challenge is Cagliari away on Monday night.
A relegation six-pointer pits together Serie A strugglers Crotone and SPAL in Sunday’s early kick-off.
Fiorentina and Chievo face off with only two Serie A victories in 2018 between them.
If there’s a side feeling more confident going into San Siro, it’s bottom of the table Benevento and not Inter.
Juventus look for their tenth consecutive league win when they host a dangerous Atalanta side who have already proven capable of stealing points from the Bianconeri.
Revitalised Milan aim to continue their march on the top four and this is a real head-to-head with third-placed Roma.
It’s a blast from the past for Duvan Zapata and Fabio Quagliarella, both former Udinese alumni, but there’s no time for sentiment.
Fresh off securing their place in the Europa League Round of 16, Lazio now turn their attention back to domestic affairs as they take on floundering Sassuolo on Sunday.
Verona host Torino on Sunday as the Gialloblu look for a vital three points in their fight for Serie A survival.